Rigid following of dogma will not be best for all patients

Isolated del(5q) in Patients Following Therapies for Various Malignancies May Not All Be Clinically Significant.

OBJECTIVES Deletion 5q is a common chromosomal abnormality in both de novo and therapy-related myeloid neoplasms (t-MNs). The detection of isolated del(5q) in patients following therapies for various malignancies raises serious concern for an emerging t-MN. METHODS We identified 25 patients who developed isolated del(5q) following cytotoxic therapy (n = 21) or tyrosine kinase inhibitor (TKI; ...

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Tomorrow's library: will it all be infrastructure?

The form in which knowledge is described and encapsulated has a major impact on the design of libraries and the functions performed within the library. Libraries as we known them have been primarily built to store and disseminate knowledge in book format. New technology and the changing needs of knowledge workers, which form important parts of the logocentric, practicentric, and democentric ele...

Whether all patients with Central precocious puberty should be treated?

Extended Abstract   Precocious puberty is the appearance of secondary sexual characteristics before 8 years old in girls and 9 years old in boys. Precocious puberty is divided into 3 groups of central, peripheral and normal variants. Central precocious puberty is accompanied by activation of hypothalamic-pituitary-gonadal axis which causes increase in secretion of GnRH, and in turn increase i...

Best practices in the management of newly diagnosed multiple myeloma patients who will not undergo transplant.

No survival advantage of autologous stem cell transplantation (ASCT) has been documented for patients older than 65 years, and in the era of thalidomide (Thalomid), bortezomib (Velcade), and lenalidomide (Revlimid), ASCT has a diminished role in the front-line treatment of older patients with myeloma. For these individuals and for those who cannot or choose not to undergo ASCT, the initial trea...